Wei L, Wu S, Shi W, Aldrich A, Kielian T, Carlson MA, et al.Three-Dimensional (3D) Fibronectin Nano-Array Presented on Fibrin Matrix Accelerates Mice Skin Wound Healing. Poblete Jara C, Wang O, do Prado PT, Ismail A, Fabian FM, Carlson MA, et al.Collateral development and arteriogenesis in hindlimbs of domestic swine after ligation of arterial inflow. Gao Y, Patel NS, Aravind S, Fuglestad M, Ungar JS, Carlson MA, et al.Fast Transformation of 2D Nanofiber Membranes into Pre-molded 3D Scaffolds with Biomimetic and Oriented Porous Structure for Biomedical Applications. Chen S, John JV, McCarthy A, Carlson MA, Li X, Xie J.Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig: preliminary report. Patel NS, Bailey K, Lazenby AJ, Carlson MA.Novel Fibrin-Fibronectin Matrix Accelerates Mice Skin Wound Healing. Study of human dermal fibroblast biology focuses on signaling pathways involved in senescence, death, proliferation, migration, and extracellular matrix reorganization by this multi-purpose cell of healing. Approaches to these problems being developed in our collaborative research program include the use of expansile biocompatible foam, recombinant human clotting proteins, and nanoengineered biomaterials. Unsolved problems in severe traumatic hemorrhage include (1) noncompressible torso hemorrhage and (2) uncontrolled junctional hemorrhage. Current areas of interest include biomaterials for tissue replacement and cell-based therapies for ischemic skeletal muscle. Therefore, the use of large animal models in regeneration research should result in more efficient development of regenerative therapies. The general belief is that the biology and physiology of humans will be more accurately reflected by large animal models (such as in swine) than by the traditional rodent models. The emphasis here is on the use of large animal models to develop regenerative therapies, including stem-cell based therapies, for treatment of conditions involving tissue loss and/or organ dysfunction. Validated large animal models of cancer will have numerous advantages over traditional small animal (mouse) models. Swine are being utilized for this purpose. The primary focus in our laboratory is the development of novel large animal models of solid epithelial tumors, including pancreatic and breast, with plans to include rectal cancer. Technology Interests: Surgical Instrument Development (Minimally Invasive and Open Surgery) Synthetic Surgical Mesh for Hernia Surgery Hemostatic Devices for Emergency and Elective Surgery Residency: Medical College of Wisconsin, Milwaukee, WIįellowship: Minimally Invasive Surgery at the Medical College of Wisconsin, Milwaukee, WI Wound Healing at the University of Texas Southwestern Medical School, Dallas, TXīoard Certification: American Board of SurgeryĪcademic Appointments: Professor of Surgery Professor, Department of Genetics, Cell Biology and Anatomy (courtesy)Ĭlinical Interests: Minimally Invasive Surgery Abdominal Wall Surgery Antireflux Surgery Gastrointestinal Malignancy Biliary Disease Graduate: Case Western Reserve University School of Medicine, Cleveland, OH Staff Surgeon VA Nebraska Western-Iowa Health Care System Surgery 112, VA Medical Center 4101 Woolworth Avenue Omaha, NE 68105 Phone: 40 Curriculum Vitae Professor, Department of Surgery Professor, Department of Genetics, Cell Biology and Anatomy (courtesy) Director, Center for Advanced Surgical Technology (CAST) University of Nebraska Medical Center Phone: 40 Fax: 40
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